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Coccidiosis is a common disease that affects the intestinal health of poultry worldwide. Susceptible animals exposed to Eimeria strains through fecal-oral transfer develop intestinal lesions that result in low weight gain, poor feed conversion, and mortality. Treatment with anticoccidial drugs has led to resistant strains of Eimeria and vaccination is now the preferred method for prevention. Vaccines elicit a pathogen-specific immune response that protects the animals against further parasitic challenge. Proliferation of these vaccines in live chickens poses a significant cost and a concerning animal welfare issue. 球蟲病是一種影響全球家禽腸道健康的常見疾病。通過糞 - 口轉(zhuǎn)移暴露于艾美球蟲菌株的易感動(dòng)物會(huì)發(fā)生腸道病變，導(dǎo)致體重增加低，飼料轉(zhuǎn)化率低和死亡率低。用抗球蟲藥物治療已導(dǎo)致艾美球蟲的抗性菌株，并且疫苗接種現(xiàn)在是預(yù)防的優(yōu)選方法。疫苗引發(fā)病原體特異性免疫反應(yīng)，保護(hù)動(dòng)物免受進(jìn)一步的寄生蟲攻擊。這些疫苗在活雞中的增殖造成了巨大的成本和涉及動(dòng)物福利的問題。有興趣的投稿個(gè)人（或企業(yè)）請(qǐng)將稿件發(fā)送到: https://www.innocentive.com/ar/solution/9934121 如果遇到任何問題，請(qǐng)留言聯(lián)系 [更多]

生產(chǎn)研發(fā)>>工藝技術(shù)

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richard16 2018-08-03 12:03 IP：重慶

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最高2萬美金懸賞：改進(jìn)的RNA復(fù)制子疫苗的配方的方案

For more than two centuries, vaccines been used to generate protective immunity against diseases. Vaccines generally contain attenuated viruses, inactivated viruses/toxins, or pathogenic subunits. Nucleic acid-based vaccines induce a cell-mediate immune response without the presence of adjuvants, thus providing an advantage over subunit vaccines; they are also incapable of infecting the host, so they are a safer alternative compared to attenuated versions. The Seeker is searching for formulation improvements with a focus on RNA replicon vaccines. 兩個(gè)多世紀(jì)以來，疫苗一直用于產(chǎn)生針對(duì)疾病的保護(hù)性免疫。疫苗通常含有減毒病毒，滅活病毒/毒素或致病亞單位?；诤怂岬囊呙缭诓淮嬖谧魟┑那闆r下誘導(dǎo)細(xì)胞介導(dǎo)的免疫應(yīng)答，因此提供優(yōu)于亞單位疫苗的優(yōu)勢(shì); 它們也無法感染宿主，因此與減毒版相比，它們是更安全的替代品。搜索者正在尋找配方改進(jìn)，重點(diǎn)是RNA復(fù)制子疫苗。有興趣的投稿個(gè)人（或企業(yè)）請(qǐng)將稿件發(fā)送到: https://www.innocentive.com/ar/solution/9934123 如果遇到任何問題，請(qǐng)留言聯(lián)系 [更多]

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wangruping 2018-05-11 11:07 IP：北京

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注射用腺苷鈷胺一致性評(píng)價(jià)調(diào)研評(píng)估及報(bào)價(jià)報(bào)告

腺苷鈷胺藥物報(bào)告，做注射用腺苷鈷胺一致性評(píng)價(jià)調(diào)研評(píng)估以及報(bào)價(jià)報(bào)告 [更多]

生產(chǎn)研發(fā)>>工藝技術(shù)