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  • qiyan_xiao 2022-11-03 16:04 IP:廣州
    2,6-二甲基苯胺作為基因毒性雜質(zhì)控制,它的每日最大攝入量是多少?(1.5μg/天做不到)目前找到一個雷諾嗪緩釋片在澳洲申報的資料中提到2,6-二甲基苯胺的每日最大攝入量范圍是20.4μg/天~110μg/天,有沒有哪位大神知道這兩個值的來源及推導(dǎo)過程,求助。原文如下:The sponsor also commissioned two nonclinical risk assessments on DMA relative to  potential exposure from ranolazine under the conditions of use. Both assessors referred to  methodologies advocated in the ICH guideline.21 The updated guideline permits the use of  compound-specific assessments (compared with. TTC-based acceptable intake of  1.5 μg/day) when sufficient carcinogenicity data exists, such that a compound-specific  acceptable intake can be extrapolated from measures of carcinogenic potency. Information  on the carcinogenicity of DMA is available from a 2 year dietary study in rats (NTP, 1990)  and is the only source of data on carcinogenic potency. The first nonclinical assessor referred to a follow-up report to the NTP report where  carcinogenic potential (TD50) was set at 20.4 mg/kg. By linear extrapolation the  acceptable lifetime daily intake was calculated as 0.41 μg/kg/day (24.5 μg/day for 60 kg  adult or 20.4 μg/day for 50 kg adult). The amount of DMA detected in 750 mg ranolazine  tablets after 24 months storage (1.6 μg/tablet or 3.2 μg/day based on average batch values  outlined above in Table 7) were at least 6.4 fold lower than the extrapolated acceptable  lifetime daily intake of 20.4 μg/day (for 50 kg adult at the MRHD). The assessor indicated  that this was an acceptable safety factor but recommended that the shelf life of Ranexa be  no more than 24 months to ensure ranolazine degradation was minimal. The second nonclinical assessor evaluated risk assessments conducted by other regulatory  bodies where acceptable daily levels of DMA ranged between 20.4 μg/day to 110 μg/day  (for 50 kg adult). The most conservative approach gave acceptable daily levels of  29 μg/day (20.4 μg/day for 50 kg adult) and was the same as that   [更多]
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    nongzr123456 2022-08-12 15:18 IP:廣州
    求購利伐沙班干混懸劑質(zhì)量信息(J..X..,清晰電子版   [更多]
    懸賞
    ¥50.00
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    yingfakeji 2022-09-26 15:23 IP:丹東
    氨基酮戊酸丙酯皮膚體表吸收的結(jié)論報告,要求檢測機(jī)構(gòu)官方合法,報告要一式三份,有公章。檢測該產(chǎn)品不參與代謝,無藥理作用,不被吸收的報告.   [更多]
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    ¥200.00
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    guijiang 2022-10-21 10:45 IP:南寧
    含量、有關(guān)物質(zhì)、溶出等方式的全驗(yàn)證資料一套   [更多]
    懸賞
    ¥50.00
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    sukikiy0 2022-10-31 13:24 IP:天津
    禮安 2022-04-09 15:58 IP:成都
    詳細(xì)要求:蔗糖氫氧化氧鐵咀嚼片參比質(zhì)量信息 、工藝信息等,最好含有復(fù)核說明和老師意見。   [更多]
    懸賞
    ¥200.00
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    sukikiy0 2022-10-25 14:26 IP:天津
    88hanpeng 2022-10-19 11:04 IP:廣州
    求購注射用頭孢哌酮鈉舒巴坦鈉質(zhì)量信息(已過一致性評價)   [更多]
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    ¥450.00
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    guijiang 2022-09-06 14:45 IP:河池
    求購IQOQ驗(yàn)證文件模板(島津液相或沃特斯液相等)   [更多]
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    ¥100.00
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    guijiang 2022-09-12 19:59 IP:南寧
    求購液相或其他檢測儀器計算機(jī)化系統(tǒng)驗(yàn)證整套文件模板   [更多]
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    ¥100.00
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