1.上市許可持有人（委托生產(chǎn)）生產(chǎn)許可證（B證）的MAH質(zhì)量管理體系全套文件及文件目錄 2.要求2020年11月后通過生產(chǎn)許可證檢查的全套文件，價格可以協(xié)商 。 3.包含四大體系文件。   [更多]

求購氨溴特羅口服溶液質(zhì)量標(biāo)準(zhǔn)或者最新的注冊標(biāo)準(zhǔn)   [更多]

詳細(xì)要求：江蘇紅豆杉藥業(yè)有限公司接受抗腫瘤藥的委托生產(chǎn)，擁有小容量注射劑（非最終滅菌、抗腫瘤藥）、凍干粉（抗腫瘤藥）的生產(chǎn)線，尋找沒有生產(chǎn)線需要委托生產(chǎn)、中試放大生產(chǎn)的公司。 具體要求：提供需要委托生產(chǎn)的公司名稱、聯(lián)系人、聯(lián)系方式，并最終合作成功。 交稿方式：直接點(diǎn)擊交稿在線交稿就是了，我會每天過來看的，謝謝各位藥智的戰(zhàn)友們   [更多]

求購一份腸內(nèi)營養(yǎng)粉劑（TP）質(zhì)量信息全文，謝謝   [更多]

重金求購艾拉莫德片原研質(zhì)量標(biāo)準(zhǔn)+工藝信息模版,需要最新版的資料   [更多]

左卡尼汀注射液   過評質(zhì)量信息   [更多]

產(chǎn)品：間苯三酚口服凍干片（Spasfon-Lyoc） 廠家：TEVA 上市國家：法國 具體的凍干工藝和處方   [更多]

東莨菪堿貼片（可彌特） 【英 文 名】 Scopolamine Patch(Kimite) 【生產(chǎn)廠商】 韓國　MyungMoon Pharmaceutial Co.,Ltd. 【 規(guī) 格 】 0.75mg、1.5mg 【注冊證號】 H20040569、H20040570 【標(biāo) 準(zhǔn) 號】 JX20010447   [更多]

求購地夸磷索鈉原料藥質(zhì)量信息（原研，清晰電子版）   [更多]

2,6-二甲基苯胺作為基因毒性雜質(zhì)控制，它的每日最大攝入量是多少？（1.5μg/天做不到）目前找到一個雷諾嗪緩釋片在澳洲申報(bào)的資料中提到2,6-二甲基苯胺的每日最大攝入量范圍是20.4μg/天~110μg/天，有沒有哪位大神知道這兩個值的來源及推導(dǎo)過程，求助。原文如下：The sponsor also commissioned two nonclinical risk assessments on DMA relative to  potential exposure from ranolazine under the conditions of use. Both assessors referred to  methodologies advocated in the ICH guideline.21 The updated guideline permits the use of  compound-specific assessments (compared with. TTC-based acceptable intake of  1.5 μg/day) when sufficient carcinogenicity data exists, such that a compound-specific  acceptable intake can be extrapolated from measures of carcinogenic potency. Information  on the carcinogenicity of DMA is available from a 2 year dietary study in rats (NTP, 1990)  and is the only source of data on carcinogenic potency. The first nonclinical assessor referred to a follow-up report to the NTP report where  carcinogenic potential (TD50) was set at 20.4 mg/kg. By linear extrapolation the  acceptable lifetime daily intake was calculated as 0.41 μg/kg/day (24.5 μg/day for 60 kg  adult or 20.4 μg/day for 50 kg adult). The amount of DMA detected in 750 mg ranolazine  tablets after 24 months storage (1.6 μg/tablet or 3.2 μg/day based on average batch values  outlined above in Table 7) were at least 6.4 fold lower than the extrapolated acceptable  lifetime daily intake of 20.4 μg/day (for 50 kg adult at the MRHD). The assessor indicated  that this was an acceptable safety factor but recommended that the shelf life of Ranexa be  no more than 24 months to ensure ranolazine degradation was minimal. The second nonclinical assessor evaluated risk assessments conducted by other regulatory  bodies where acceptable daily levels of DMA ranged between 20.4 μg/day to 110 μg/day  (for 50 kg adult). The most conservative approach gave acceptable daily levels of  29 μg/day (20.4 μg/day for 50 kg adult) and was the same as that   [更多]